Robert A. Pearce
Position title: Professor, Department of Anesthesiology
Email: rapearce@wisc.edu
Phone: (608) 263-0208
Address:
Research Interests: Mechanisms by which general anesthetics alter brain function, understanding how modulation of GABAA receptors impairs memory, utilizing expressed recombinant receptors and hippocampal brain slices to investigate the roles of specific subunit combinations and cell types in the control of learning and memory.

Education
- B.S. 1979 University of Colorado, Boulder, CO
- M.D./Ph.D. 1986 University of Virginia, Charlottesville, VA
- Residency 1989 University of Virginia, Charlottesville, VA
Publications
- Wake Up, Neurons! Astrocytes Calling.
Author(s) Perouansky M, MacIver MB, Pearce RA
Date 2019 Mar Journal Name Anesthesiology
Volume 130 Issue 3 Pages 361-363 ISSN 0003-3022 ESSN 1528-1175 - Doc2-mediated superpriming supports synaptic augmentation.
Author(s) Xue R, Ruhl DA, Briguglio JS, Figueroa AG, Pearce RA, Chapman ER
Date 2018 Jun 12 Journal Name Proceedings Of The National Academy Of Sciences Of The United States Of America
Volume 115 Issue 24 Pages E5605-E5613 ISSN 0027-8424 ESSN 1091-6490 - Contrasting Effects of the γ-Aminobutyric Acid Type A Receptor β3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB.
Author(s) Amlong CA, Perkins MG, Houle TT, Miller KW, Pearce RA
Date 2016 Nov Journal Name Anesthesia And Analgesia
Volume 123 Issue 5 Pages 1241-1246 ISSN 0003-2999 ESSN 1526-7598 - Lipid-free Fluoropolymer-based Propofol Emulsions and Lipid Reversal of Propofol Anesthesia in Rats.
Author(s) Parks CL, Tucker W, Amlong CA, Mecozzi S, Pearce RA
Date 2016 Jun Journal Name Anesthesiology
Volume 124 Issue 6 Pages 1328-37 ISSN 0003-3022 ESSN 1528-1175 - Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference.
Author(s) Engin E, Zarnowska ED, Benke D, Tsvetkov E, Sigal M, Keist R, Bolshakov VY, Pearce RA, Rudolph U
Date 2015 Oct 7 Journal Name The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Volume 35 Issue 40 Pages 13698-712 ISSN 0270-6474 ESSN 1529-2401 - Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells.
Author(s) Rodgers FC, Zarnowska ED, Laha KT, Engin E, Zeller A, Keist R, Rudolph U, Pearce RA
Date 2015 Jul 1 Journal Name The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Volume 35 Issue 26 Pages 9707-16 ISSN 0270-6474 ESSN 1529-2401 - Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor.
Author(s) Zarnowska ED, Rodgers FC, Oh I, Rau V, Lor C, Laha KT, Jurd R, Rudolph U, Eger EI Nd, Pearce RA
Date 2015 Jun Journal Name Neuropharmacology
Volume 93 Pages 171-178 ISSN 0028-3908 ESSN 1873-7064 - Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS.
Author(s) Gemperline E, Laha K, Scarlett CO, Pearce RA, Li L
Date 2014 Aug 21 Journal Name Analytical Methods : Advancing Methods And Applications
Volume 6 Issue 16 Pages 6389-6396 ISSN 1759-9660 ESSN 1759-9679 - Spatiotemporal characteristics and pharmacological modulation of multiple gamma oscillations in the CA1 region of the hippocampus.
Author(s) Balakrishnan S, Pearce RA
Date 2014 Journal Name Frontiers In Neural Circuits
Volume 8 Pages 150 ESSN 1662-5110 - Enhancement of α5-containing γ-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the β3(N265M) mutation.
Author(s) Burkat PM, Lor C, Perouansky M, Pearce RA
Date 2014 Dec Journal Name Anesthesia And Analgesia
Volume 119 Issue 6 Pages 1277-84 ISSN 0003-2999 ESSN 1526-7598