Faculty: Dent, Zhao, Roopra, Rosenberg, Jones, Z. Huang, Gomez
The long-term goals of the Neuroscience faculty research are to translate information gained from laboratory benches into clinical applications. Diverse model organisms have been employed by Neuroscience investigators, ranging from invertebrates to transgenic rodents and non-human primates, to identify modalities that regulate brain functions at molecular, cellular, and system levels. In addition, human stem cell models, including those from patients with neurological disorders, allow verification of observations made in animal models in bona fide, diseased human cells/tissues. Information integrated from and filtered through both animal and human model systems has shed light on the pathological development of and led to devise of gene and/or cell based strategies for neurological conditions, including developmental disorders (e.g., Rett syndrome, Autism, and Fragile X syndrome), psychiatric conditions (e.g., epilepsy), and neurodegenerative diseases (e.g., Parkinson’s disease).