Principal Investigator: Meyer Jackson, PhD
Postdoctoral positions are available to study neural circuits with imaging techniques, and exocytosis with electrophysiological techniques.
Neural circuits: We are seeking researchers to investigate the mechanisms by which neural circuits process and store information. We use imaging techniques with both synthetic and genetically-encoded voltage sensors to monitor electrical activity in intact neural circuits (rodent brain slices). Our exceptionally powerful genetically-encoded voltage sensor can be targeted to any desired cell type using Cre-loxP technology. This has created an extraordinary range of opportunities to probe fundamental aspects of circuit function and ask both basic and applied questions. We are currently using this approach to probe inhibitory microcircuits formed by interneurons. Opportunities are also available for probe development.
Exocytosis: We also seek researchers to investigate the molecular mechanism of neurotransmitter and hormone release. We use electrical and electrochemical techniques to monitor the release of single vesicles and examine how exocytosis is altered by mutations of proteins that drive membrane fusion. Research focusses on the fusion pore and adapts ideas from ion channel and membrane biophysics to the study of membrane fusion.
Highly motivated individuals are sought with a passionate interest in neuroscience. Background in neuroscience, physiology, molecular biology, or biophysics is desirable for work on either project.
Please direct inquiries to:
Dept. of Neuroscience
Principal Investigator: Xin Huang, PhD
We are looking for a highly motivated researcher to study neural coding of visual motion and depth information in the visual cortex that allows multiple objects in the visual scene to be segmented and perceived, and to study the roles of selective attention in the neural process of visual segmentation. The ideal candidate has a strong background in neurophysiology and quantitative data analysis. Experiences with electrophysiological recordings and MATLAB are helpful.
Please email a CV, research statement, relevant publications and names of two or three referees to:
Xin Huang, Ph.D.
Dept. of Neuroscience
Required Degree(s) and Area of Specialty: Ph.D. (or equivalent) in Physiology, Biochemistry, Chemistry, Biophysics or related field
Principal Investigator: Gail Robertson, PhD
We are seeking a postdoctoral trainee to study mechanisms of sudden cardiac death associated with acquired and inherited long QT syndrome (LQTS). Efforts focus on the hERG channel, the primary target of acquired LQTS and the basis of a toxicity screen used worldwide to ensure drugs in development do not cause catastrophic cardiac arrhythmias. We study biophysical properties of hERG channel gating and pharmacology, determinants of surface channel density, pathways of intracellular trafficking, and mechanisms of channel assembly and subunit composition, all of which are critical for cardiac repolarization and represent targets for perturbations resulting in LQTS. We use manual and high throughput patch clamp electrophysiology in heterologous expression systems, quantitative western blot analysis of expressed and native proteins, immunocytochemistry and a variety of screening methods for protein-protein interactions. Creative, highly motivated individuals with demonstrated strength in membrane protein biochemistry are particularly encouraged to apply, but applications in any relevant area will be considered. A strong quantitative background is highly desirable. Opportunities for technology development and commercial applications abound in this highly translational area of research.
Please submit applications to:
Gail Robertson, Ph.D.
Dept. of Neuroscience
Postdoctoral position available for studying epigenetic regulations of neural stem cells
Principal Investigator: Xinyu Zhao, PhD
A postdoctoral position is available in my laboratory to study epigenetic regulations of postnatal neurogenesis and neural stem cell functions. Potential projects include using cultured neural stem cells and gene knockout mice as model systems to investigate the effect of epigenetic factors (DNA methylation, RNA binding proteins, noncoding small RNAs) on the self-renewal and lineage determination of neural stem cells. We are seeking a highly motivated and self-directed individual with good communication, mentoring, and problem-solving skills. A strong background in mammalian cell culture, cell-based assays, and animal models is required. Knowledge in neuroscience and experience in molecular biology are desired. This position is an NIH-funded 3-year appointment. The salary and benefits are competitive US-standard
If interested, please contact Dr Zhao by email: email@example.com
UW-Madison is an equal opportunity/affirmative action employer. We promote excellence through diversity and encourage all qualified individuals to apply.
UW-Madison Academic Personnel Office