Mrinalini Hoon

Position title: Assistant Professor, Department of Ophthalmology and Visual Sciences


Phone: (608) 263-6648

Research Interests: Mammalian retinal development, maturation, disease and degeneration

Mrinalini Hoon smiling into the camera wearing a striped shirt.

Hoon Lab Website.

3395 Medical Science Center
1300 University Avenue
Madison, WI, 53706


  • B.Sc. (Hon) 2005 Calcutta University, Kolkata, India
  • Ph.D. 2010 International Max Planck Research School University of Goettingen, Goettingen, Germany
  • Postdoc 2010-2015 University of Washington, Seattle, WA, USA



  • (i) Hoon M*, Krishnamoorthy V, Gollisch T, Falkenburger B, Varoqueaux F*. PLoS One 2017 Jul 14;12(7):e0181011. Loss of Neuroligin3 specifically downregulates retinal GABAAa2 receptors without abolishing direction selectivity. * Co-corresponding authors.
  • (ii) Gore BB, Miller SM, Jo YS, Baird MA, Hoon M, Sanford CA, Hunker A, Lu W, Wong RO, Zweifel LS. Elife 2017 Apr 10;6. pii: e23858.Roundabout receptor 2 maintains Inhibitory control of the adult midbrain.
  • (iii) Sinha R*, Hoon M*, Baudin J, Okawa H, Wong RO, Rieke F*. Cell 2017 Jan 26;168(3):413-426.e12. Cellular and circuit mechanisms shaping the perceptual properties of the primate fovea. * Co-corresponding authors
  • (iv) Della Santina L, Kuo SP, Yoshimatsu T, Okawa H, Suzuki SC, Hoon M, Tsuboyama K, Rieke F, Wong RO. Curr Biol 2016 Aug 8; 26(15):2070-7.Epub 2016 Jul14. Glutamatergic monopolar interneurons provide a novel pathway of excitation in the mouse retina.
  • (v) Moore-Dotson JM, Beckman JJ, Mazade RE, Hoon M, Adam S. Bernstein AS, Romero-Aleshire MJ, Brooks HL, Eggers ED. IOVS 2016 Mar 1;57(3):1418-30. Early retinal neuronal dysfunction in diabetic mice: Reduced light-evoked inhibition increases rod pathway signaling.
  • (vi) Hoon M*, Sinha R, Okawa H, Suzuki SC, Hirano AA, Brecha N, Rieke F, Wong RO*. Proc Natl Acad Sci U S A 2015 Oct 13; 112(41): 12840-5. Epub 2015 Sep 29. Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells.* Co-corresponding authors.
  • (vii) Newkirk GS, Hoon M, Wong RO, Detwiler PB. PloS One 2015 Sep 9; 10(9): e0137702. Response properties of a newly identified tristratified narrow field amacrine cell in the mouse retina.
  • (viii) Grimes WN, Zhang J, Tian H, Graydon C, Hoon M, Rieke F, Diamond JS. J Journal of Neurophysiology 2015 Jul; 114(1):341-53 . Epub 2015 May 13. Complex inhibitory microcircuitry regulates retinal signaling near visual threshold.
  • (ix) Grimes WN, Hoon M, Briggman KL, Wong RO, Rieke F. Elife 2014 Sep 1:e03892. Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
  • (x) Newkirk GS, Hoon M, Wong RO, Detwiler PB. J Neurophysiol 2013 Jul;110(2):538-52. Epub 2013 May1. Inhibitory inputs tune the light response properties of dopaminergic amacrine cells in mouse retina.
  • (xi) Schubert T *, Hoon M *, Euler T, Lukasiewicz P, Wong RO. Neuron 2013 Apr 10;78(1):124-37. Developmental regulation and activity-dependent maintenance of GABAergic presynaptic inhibition onto rod bipolar cell axonal terminals. * These authors contributed equally to this work.
  • (xii) Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt K.F, Sassoe-Pognetto M, Loewel S, Moser T, Taschenberger H, Brose N, Varoqueaux F. Proc Natl Acad Sci U S A 2011 Feb 15; 108(7): 3053-8. Epub 2011 Jan 31. Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
  • (xiii) Jedlicka P, Hoon M, Papadopoulos T, Vlachos A, Winkels R, Poulopoulos A, Betz H, Deller T, Brose N, Varoqueaux F, Schwarzacher S. W. Cereb Cortex 2011 Feb; 21(2): 357-6. Epub 2010 Jun 7. Increased Dentate Gyrus Excitability in Neuroligin 2-Deficient Mice in Vivo.
  • (xiv) Poulopoulos A, Aramuni G, Meyer G, Soykan T, Hoon M, Papadopoulos T, Zhang M, Paarmann I, Fuchs C, Harvey K, Jedlicka P, Schwarzacher SW, Betz H, Harvey RJ, Brose N, Zhang W, Varoqueaux F. Neuron 2009 Sep 10; 63(5): 628-42. Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin.
  • (xv) Hoon M, Bauer G, Fritschy JM, Moser T, Falkenburger BH, Varoqueaux F. J Neurosci 2009 Jun 24; 29(25): 8039-50. Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina.


  • (i) Hoon M*, Sinha R, Okawa H*. Methods Mol Biol vol. 1538 (2017), Humana Press ISBN 978-1-4939-6688-2 Using fluorescent markers to estimate synaptic connectivity in situ. * Co-corresponding authors


  • (i) Gamlin C.R., Yu W., Wong R.O.L., Hoon M. Neural Development 2018 in press Assembly and maintenance of GABAergic and Glycinergic circuits in the mammalian nervous system
  • (ii) Okawa H*, Hoon M*, Yoshimatsu T, Della Santina L, Wong RO. Neuron 2014 Sep 17;83(6):1303-1318 Illuminating the Multifaceted Roles of Neurotransmission in Shaping Neuronal Circuitry. * These authors contributed equally to this work.
  • (iii) Hoon M, Okawa H, Della Santina L, Wong RO. Prog Retin Eye Res 2014 Sep;42:44-84. Functional architecture of the retina: development and disease.