Loading Events

« All Events

  • This event has passed.

Seminar: Jeremy Dittman, Cornell University, Dept of Biochemistry

10/05/2022 @ 12:00 PM - 1:00 PM

The Department of Neuroscience will host a seminar with Dr. Jeremy Dittman, Department of Biochemistry, Cornell University, in 1306 HSLC** on Wednesday, October 5th at 12:00 PM (noon). This meeting will be held in person with a Zoom option available.

**Please note the change of venue.

Dr. Dittman’s title is “Munc13 and synaptic transmission: New insights into an old protein.”

Jeremy DittmanMunc13 and synaptic transmission:
New insights into an old protein

Munc13 is a deeply conserved synaptic hub protein that coordinates nearly every aspect of neurotransmitter release, although we still lack a mechanistic understanding of its actions at the synapse.

Using a forward genetic screen in C. elegans, we identified and characterized a unique C-terminal domain that is critical for maintaining the pool of fusion-competent vesicles at the synapse (the docking/priming function of Munc13).

We also determined that a neighboring protein module comprising a C1-C2 tandem domain mediates an autoinhibitory function that is critical for proper regulation of synaptic transmission.

A human point mutation in this site leads to severe neurological dysfunction due to a gain of Munc13 activity.

Together with recent structural work on Munc13, our biochemical, genetic, and physiological data suggest a principal organizational role for Munc13 in controlling vesicle docking, SNARE assembly, and membrane fusion.


Zoom Information

Join Zoom Meeting https://uwmadison.zoom.us/j/98248357487?pwd=Y0VVVStUajZScVZHTmFQUFQ5MUFHZz09

Meeting ID: 982 4835 7487

Passcode: 103393

One tap mobile

+13126266799,,98248357487#,,,,*103393# US (Chicago)

+19292056099,,98248357487#,,,,*103393# US (New York)

Dial by your location

        +1 312 626 6799 US (Chicago)

        +1 929 205 6099 US (New York)

        +1 301 715 8592 US (Washington DC)

        +1 346 248 7799 US (Houston)

        +1 669 900 6833 US (San Jose)

        +1 253 215 8782 US (Tacoma)

Meeting ID: 982 4835 7487

Passcode: 103393

Find your local number: https://uwmadison.zoom.us/u/abZOqipmwv

Join by SIP


Join by H.323 (US West) (US East)

Meeting ID: 982 4835 7487

Passcode: 103393


12:00 PM - 1:00 PM
Event Category:


1306 HSLC