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Seminar: Jeremy Dittman, Cornell University, Dept of Biochemistry

Name: Seminar: Jeremy Dittman, Cornell University, Dept of Biochemistry
Start: 2022-10-05T12:00:00-05:00
End: 2022-10-05T13:00:00-05:00
Location: 1306 HSLC

10/05/2022 @ 12:00 PM - 1:00 PM

The Department of Neuroscience will host a seminar with Dr. Jeremy Dittman, Department of Biochemistry, Cornell University, in 1306 HSLC** on Wednesday, October 5th at 12:00 PM (noon). This meeting will be held in person with a Zoom option available.

**Please note the change of venue.

Dr. Dittman’s title is “Munc13 and synaptic transmission: New insights into an old protein.”

Munc13 and synaptic transmission:
New insights into an old protein

Munc13 is a deeply conserved synaptic hub protein that coordinates nearly every aspect of neurotransmitter release, although we still lack a mechanistic understanding of its actions at the synapse.

Using a forward genetic screen in C. elegans, we identified and characterized a unique C-terminal domain that is critical for maintaining the pool of fusion-competent vesicles at the synapse (the docking/priming function of Munc13).

We also determined that a neighboring protein module comprising a C1-C2 tandem domain mediates an autoinhibitory function that is critical for proper regulation of synaptic transmission.

A human point mutation in this site leads to severe neurological dysfunction due to a gain of Munc13 activity.

Together with recent structural work on Munc13, our biochemical, genetic, and physiological data suggest a principal organizational role for Munc13 in controlling vesicle docking, SNARE assembly, and membrane fusion.

Zoom Information

Join Zoom Meeting https://uwmadison.zoom.us/j/98248357487?pwd=Y0VVVStUajZScVZHTmFQUFQ5MUFHZz09

Meeting ID: 982 4835 7487

Passcode: 103393

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