Nichol RH 4th, Hagen KM, Lumbard DC, Dent EW, Gómez T.M.

J Neurosci. 2016 Feb 17;36(7):2267-82. doi: 10.1523/JNEUROSCI.2645-15.2016.

PMID: 26888936




GSantiago-Medina, M., UGregus, K. A., Nichol, R.H. and Gomez, T.M. Regulation of ECM degradation

and axon guidance by growth cone invadosomes.  Development, Feb 1, 142(3):486-496.

Highlighted in Science magazine.  Faculty of 1000 selection. PMCID: PMC4493769


GKerstein, P., GNichol, R., Gomez T.M. (2015) Mechanochemical regulation of growth cone motility.

 Front Cell Neurosci, Jul 7;9:244. PMCID: PMC 4493769




Gomez, T.M. and LeTourneau, P.C. (2014).  Actin Dynamics in growth cone motility and navigation.

J Neurochem, Apr; 129(2):221-234. PMCID: PMC3980044


Doers M.E., Musser M.T., GNichol R., Baker M.W., Berndt E.R., Gomez T.M., Zhang S.C.,

Abbeduto L., Bhattacharyya A. (2014). Induced Pluripotent stem cell derived forebrain

neurons from FXS individuals show defects in initial neurite outgrowth.  Stem Cells Dev.

March 24. 23 (15): 1777-1787. PMCID: PMC4103262


Wang, Z.Y., McDowell, T., Wang, P., Alvarez, R., Gomez T.M., Bjorling, D.E. (2014) Activation

of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons.

Neuroscience, Sep 26;277:679-89679-89689. PMCID: 25088915




GKerstein, P., GJacques-Fricke, B., PRengifo J., Mogen, B., Williams, J.,  Gottlieb, P., Sachs, F.

and Gomez, T.M. (2013)  Mechanosensitive TRPC1 channels promote calpain proteolysis of

talin to regulate spinal axon outgrowth.  J Neurosci, Jan 2, 33(1): 273-285.  PMCID: 3539200




GMyers, J.P., GRobles, E., UDucharme-Smith, A. and Gomez, T.M. (2013) Focal adhesion

kinase modulates CDC42 activity downstream of positive and negative axon guidance cues.

J Cell Science. 125 (pt 12): 2918-2929. PMCID: 3434813




Hengen, K.B., Gomez, T.M., Stang K.M., Johnson, S.M. and Behan, M. (2011) Changes in

ventral respiratory column GABAaR {varepsilon} and {delta} subunits during hibernation

mediate resistance to depression by EtOH and pentobarbital.  Am J Physiol and Regul Integr

Com Physiol. 2011 Feb; 300(2):R272-83. PMCID:3043800.


GSantiago-Medina, M., GMyers, J.P. and Gomez T.M. (2011) Imaging adhesion and signaling

dynamics in Xenopus Laevis growth cones. Dev. Neurobio. Apr; 72(4):585-599.  PMCID:



GMyers, J.P., GSantiago-Medina, M. and Gomez T.M. (2011) Regulation of axonal outgrowth

and pathfinding by integrin-ECM interactions. Dev. Neurobio. 71 (11):901-923. PMCID:



Gomez, T.M. (2011) Pioneering studies on the mechanism of neuronal morphogenesis.

Sep;71(9):78--784. Dev. Neurobio. PMCID: PMC3482615


GMyers, J.P. and Gomez, T.M. (2011) Focal adhesion kinase promotes integrin adhesion

dynamics necessary for chemotrophic turning of nerve growth cones.  J Neurosci.

21 September; 31(38):13585-13595. PMCID: 3193056




GMoon, M-S and Gomez, T.M. (2010) Balanced Vav2 GEF activity regulates neurite

outgrowth and branching in viro and in vivo.  Mol. Cell. Neurosci.  Jun; 44(2): 118-128.

PMCID: 2862809




GWoo, S. W., URowan, D.J. and Gomez, T.M. (2009) Retinotopic mapping requires

FAK-mediated regulation of growth cone adhesion. J Neurosci. 29(44): 13981-13991.





Marriott, G., Mao, S., Sakata, T., Ran, J., Jackson, D.K., Petchprayoon, C., Gomez, T.M., Warp, E.,

Tulyathan O., Aaron, H.L., Isacoff, E.Y. and Yan, Y. (2008).  Optical lock-in detection imaging

microscopy for contrast-enhanced imaging in living cells. Proc Natl Acad Sci USA.  105:

17789-17794. PMCID: 2584753.




Kholmanskikh, S. S., Koeller, H.B., Wynshaw-Boris, A., Gomez, T.M., Letourneau, P.C. and

Ross, E.M. (2006). Calcium-dependent interaction of lis1 with IQGAP1 and CDC42 promotes

neuronal motility. Natur Neurosci., 9, 50-57


Gomez, T.M. and Zheng, J. (2006). The molecular basis for calcium-dependent axon

pathfinding. Nature Reviews Neuroscience, 7, 115-125.


GWoo, S.W. and Gomez, T.M. (2006). Rac1 and RhoA promote neurite outgrowth through

formation and stabilization of growth cone point contacts. J Neurosci. 26(5) 1418-1428.


GJacques-Fricke, B.T., USeow, Y., Gottlieb, P.A., Sachs, F. and Gomez, T.M. (2006). Opposing

regulation of neurite growth by Ca2+ influx through a mechanosensitive channel and

release from intracellular stores. J Neurosci. 26(21), 5656-5664.


GRobles, E. and Gomez, T.M. (2006). Focal adhesion kinase signaling at sites of integrin

mediated adhesion controls axon pathfinding. Nature Neurosci., 9 (10), 1274-1283.


Pal, S., Jing, W., Murray J.T., Gellman, S.H., Wozniak, M.A. Keely, P.J., Bover, M.E., Gomez, T.M.,

Hasso, S.M., Fallon, J.F. and Bresnick, E.H. (2006).  An antiangiogenic neurokinin-B/thromboxane

A2 regulatory axis.  J. Cell Bio., 174(7):1047-1058.




Gomez, T.M. (2005).  Neurobiology: channels for pathfinding.  Nature. 434, 835-838.


GRobles, E., GWoo, S and Gomez, T.M. (2005) Coincident Src and Cdc42 signals at the tips

of growth cone filopodia and regulate protrusion. J Neurosci. 25(33), 7669-7681.


GMoon, M-s and Gomez, T.M. (2005).  Adjacent pioneer commissural interneuron growth

cones switch from contact avoidance to axon fasciculation after midline crossing.

Devlp. Biol., 288, 474-486.




Gomez, T.M., GRobles, E. (2004). The great escape: phosphorylation of Ena/VASP by

PKA promotes filopodial formation. Neuron 42, 1-3.




GRobles, E., Huttenlocher, A, Gomez, T.M. (2003). Filopodial calcium transients regulate

growth cone motility and guidance through local activation of calpain. Neuron, 38, 597-609.


G Graduate student

U Undergraduate Student

P Post-doctoral fellow


As post-doctoral fellow:


Gomez, T.M. and Spitzer, N.C.(1999).  In vivo regulation of axon extension and pathfinding

by growth cone calcium transients.  Nature 397, 350-355. (Mini-review in Neuron).


Spitzer, N.C., Lautermilch, N.J., Smith, R.D. and Gomez, T.M. (2000). Coding of neuronal

differentiation by calcium transients.  BioEssays. 22, 811-817.


Gomez, T.M., and Spitzer, N.C. (2000).  Regulation of growth cone behavior by calcium:

new dynamics to earlier perspectives.  J Neurobiology. 44, 174-183.


Gomez, T.M., Robles, E., Poo, M-m and Spitzer, N.C.(2001).  Filopodial calcium transients

promote substrate-dependent growth cone turning. Science, 291, 1983-1987.

(Comment in Scientific American)


As a Graduate Student:


Letourneau, P.C., Snow, D.M., and Gomez, T.M. (1994). Regulation of growth cone motility

by substratum bound molecules and cytoplasmic [Ca2+].  Prog Brain Res 103, 85-98.


Gomez, T.M., and Letourneau, P.C. (1994). Filopodia initiate choices made by sensory

neuron growth cones at laminin/fibronectin borders in vitro. J Neurosci 14,



Gomez, M.R., and Gomez, T.M. (1995).  Regulation of cell migration and axon pathfinding

assessed with experimental and disease models. Acta. Neuropediatria 1, 228-238.


Gomez, T.M., Snow, D.M., and Letourneau, P.C. (1995). Characterization of spontaneous

calcium transients in nerve growth cones and their effect on growth cone migration.

Neuron 14, 1233-1246.


Gomez, M.R., and Gomez, T.M. (1996).  Experimental pathological models that explain

the regulation of cellular migration and axon's orientations. Rev Neurol 23, 1351-1355.


Gomez, T.M., Roche, F.K., and Letourneau, P.C. (1996) Chick sensory neuronal growth

cones distinguish fibronectin from laminin by making substratum contacts that resemble

focal contacts. J. Neurobiology 29, 18-34.